![]() The present study was carried out to investigate whether methanolic extract of Phalleria macrocarpa (Scheff) Boerl fruits (PM) mitigates oxidative stress in fructose fed rats. ![]() Further separation of the n-hexane exctrat using TLC in n-hexane ethyl acetate amonia (66:33:0.8) yielded 5 spots with the Rf of 0.3 0.44 0.54 0.72 and 0.78, respectively. The presence of steroids were detected in both extract whilst the alkaloids were only detected in the ethanol extract. The result showed that both ethanol and n-hexane exctracts performed toxicity level against brine shrimp larvae of A.salina Leach with LC50less than 1000 ppm.The n-hexane extract indicated LC50 of 189.093 ppm, higher than the ethanol extract, 286.031 ppm. The phytochemical assay and thin layer chromatography (TLC) was also apllied for both extracts. The mortality data of A.salina Leach was analysed using probit analysis to determine the value of LC50 on each extract. The research was conducted by extracting samples using both ethanol and n-hexane solvents.The concentrated extract obtained then were used for the toxicity test against brine shrimp larvae of A.salina Leach (BSLT). The information would be beneficial for anticancer drug discovery. The aim of this research was to determine the level of the toxicity against brine shrimp larvae A.salina Leach in each dried sea cucumber (H.scabra) extract collected from Kenjeran Coast, Surabaya. It has been hundreds years consumed for drug to cure various diseases in China. Sea cucumber (H.Scabra)is a species of marine biota providing high economicaland medical values. Myocardial damage in rats induced by Doxorubicin. ![]() The results suggest that ethanolic extracts PM with doses of 7.5%, 10% and 12.5% can repair Sections of 4 μm in thickness were stained with hematoxylin and eosin, and examined under a Each specimen fixed in 10% formalin solution was embedded in Heart samples from each group were prepared for histopathological assessmentĪnd placed in 10% neutral buffered formalin. Rats from each group were anesthetized with urethane (120 mg/100 mg, i. Treatment for 15 days in accordance with the distribution of the group. On day 11 after the induction of doxorubicin, rats given the Injection intraperitoneally for 3 consecutive days. At theīeginning of the experiment, all animals, except normal control group induced doxorubicin 35mg/kg BW by Mg/200 mg BW, and ethanol extract of Phaleria macrocarpa (PM) at the dose 7,5%, 10% and 12,5%. ![]() The rats (n=30) were divided into six groups (of five each) normal control, negative control, Ramipril 0,09 Abstract: Research has conducted to determine the effect of ethanol extract Phaleria macrocarpa (Scheff)īoerl.] against heart damage induced by Doxorubicin in rats (Rattus norvegicus L.) by histological study. ![]()
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